hazemessam/esm3_ddg_v2 · Model results

Hi,

Thanks for sharing the model! I have tried it on some protein of interest, and unfortunately, the results are ~50% accurate. Also, the model performs much lower in methods such as FoldX or Pythia. It would be great to have an ESM3-based model for the prediction of ddG, but I think this one is not there yet. Would you include the instructions for fine-tuning it for the target proteins? Do you know if the ESM3 is structure-sensitive, as the embeddings also contain the mutated residue's structural information and neighbors?

Thanks!