text
stringlengths 57
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| relation
stringclasses 125
values | h
dict | t
dict |
|---|---|---|---|
mevalonolactone treatment resulted in increases in liver cholesterol content and in the cholesterol ester concentration of liver microsomes . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
57,
68
]
} | {
"id": "C0008387",
"name": "cholesterol ester",
"pos": [
88,
105
]
} |
lactobacillus delbrueckii 7469 , however , which specifically requires pyridoxamine-p or pyridoxal-p for growth , accumulates both these compounds and pyridoxine-p from the medium , apparently by active transport , but not pyridoxine , pyridoxamine , or pyridoxal . | NA | {
"id": "C0034266",
"name": "pyridoxal-p",
"pos": [
89,
100
]
} | {
"id": "C0034272",
"name": "medium",
"pos": [
173,
179
]
} |
while pyridoxal-p and pyridoxamine-p are interconvertible in this organism , pyridoxine-p is not further metabolized , thus accounting for the specificity of the growth requirement . | NA | {
"id": "C0034266",
"name": "pyridoxal-p",
"pos": [
6,
17
]
} | {
"id": "C0034272",
"name": "pyridoxine",
"pos": [
77,
87
]
} |
these observations run counter to the expectation that synthetases in bacteria and yeast are negatively regulated by free amino acids , or , more likely , by aminoacyl-trna . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
122,
133
]
} | {
"id": "C0035714",
"name": "aminoacyl-trna",
"pos": [
158,
172
]
} |
prostaglandin endoperoxide e isomerase catalyzes the isomerization of the endoperoxy group of prostaglandin h and produces prostaglandin e . | NA | {
"id": "C0033554",
"name": "prostaglandin",
"pos": [
0,
13
]
} | {
"id": "C0033559",
"name": "prostaglandin e",
"pos": [
123,
138
]
} |
impaired conversion of procollagen to collagen by fibroblasts and bone treated with tunicamycin , an inhibitor of protein glycosylation . | NA | {
"id": "C0033235",
"name": "procollagen",
"pos": [
23,
34
]
} | {
"id": "C0009325",
"name": "collagen",
"pos": [
38,
46
]
} |
these findings provide additional support for the involvement of more than one enzyme in the limited proteolytic conversion of procollagen to collagen . | NA | {
"id": "C0033235",
"name": "procollagen",
"pos": [
127,
138
]
} | {
"id": "C0009325",
"name": "collagen",
"pos": [
142,
150
]
} |
at still lower ph values , 5.0 to 5.5 , ( ca2+ , mg2+ ) -atpase was inactivated while mg2+ atpase was more acid-resistant . | NA | {
"id": "C0001473",
"name": "atpase",
"pos": [
57,
63
]
} | {
"id": "C0001477",
"name": "mg2",
"pos": [
86,
89
]
} |
prr titrations enabled the measurement of binding of creatine to the ternary ch3s-enzyme-mnadp complex and show that specific anions such as nitrate , formate , and thiocyanate decrease the apparent dissociation constant for creatine in its complex with the ch3s-blocked enzyme and mnadp , as is observed with native creatine kinase . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
126,
132
]
} | {
"id": "C0028125",
"name": "nitrate",
"pos": [
141,
148
]
} |
consistent with the diminished influence of these anions on the prr enhancement of the ch3s-enzyme-mnadp-creatine complex , epr spectra of bound mn ( ii ) show that the ch3s-blocking group interferes with the pronounced anion-induced spectral changes which are observed with the native enzyme . | NA | {
"id": "C0026741",
"name": "enzyme",
"pos": [
92,
98
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
286,
292
]
} |
these and other experiments suggest that htyroid peroxidase is , like several other peroxidases , a glycoprotein . | NA | {
"id": "C0027021",
"name": "peroxidase",
"pos": [
49,
59
]
} | {
"id": "C0031179",
"name": "peroxidases",
"pos": [
84,
95
]
} |
purified rat liver albumin mrna directed the synthesis of albumin in a mrna-dependent cell-free protein-synthesizing system derived from wheat germ extracts . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
19,
26
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
96,
103
]
} |
the [ 3h ] leucine-labeled in vitro translation product reacted with antibodies specific for albumin and co-migrated with authentic 14c-labeled serum albumin during gel electrophoresis in the presence or absence of sodium dodecyl sufate . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
93,
100
]
} | {
"id": "C0036773",
"name": "serum",
"pos": [
144,
149
]
} |
when enzyme that has its essential thiol derivatized with cyanide is incubated with udp- [ 14c ] glucose and nad+ , and then reduced with nab3h4 , a stable enzyme complex is formed which contains both labels . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
5,
11
]
} | {
"id": "C0026741",
"name": "enzyme complex",
"pos": [
156,
170
]
} |
we now describe a method for rapid and reliable separation of precursor and rtf-transformed receptor forms , which takes advantage of a difference in isoelectric point between the two : the more acidic precursor ( isoelectric point , 6.2 ) is still retained by deae-cellulose under conditions ( 0.12 m kcl , ph 8.3 ) which produce release from cellulose of the less acidic transformed form ( isoelectric point , 6.6 to 6.8 ) . | NA | {
"id": "C0011050",
"name": "deae-cellulose",
"pos": [
261,
275
]
} | {
"id": "C0007648",
"name": "cellulose",
"pos": [
344,
353
]
} |
rtf attacks native casein ( km , 1.25 x 10 ( -5 ) mol/liter at ph 7.5 and 22 degrees ) but not hemoglobin , ovalbumin , or albumin . | NA | {
"id": "C0029923",
"name": "ovalbumin",
"pos": [
108,
117
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
123,
130
]
} |
two cellulases purified from growing regions of auxin-treated peas ( buffer-soluble and buffer-insoluble ) hydrolyze cellulose powder , partially substituted carboxymethylcellulose ( cm-cellulose ) , higher cellodextrins , and certain mixed linkage glucans ( e.g . barley beta-glucan ) , at rates comparable to these reported for the most active fungal cellulases , and with kinetics and product formation characteristic of endohydrolase action . | NA | {
"id": "C0007648",
"name": "cellulose",
"pos": [
117,
126
]
} | {
"id": "C0017696",
"name": "glucans",
"pos": [
249,
256
]
} |
two cellulases purified from growing regions of auxin-treated peas ( buffer-soluble and buffer-insoluble ) hydrolyze cellulose powder , partially substituted carboxymethylcellulose ( cm-cellulose ) , higher cellodextrins , and certain mixed linkage glucans ( e.g . barley beta-glucan ) , at rates comparable to these reported for the most active fungal cellulases , and with kinetics and product formation characteristic of endohydrolase action . | NA | {
"id": "C0017696",
"name": "glucans",
"pos": [
249,
256
]
} | {
"id": "C1134651",
"name": "beta-glucan",
"pos": [
272,
283
]
} |
release of alanine and glutamine accounted for approximately 50 % of the total change in perfusate amino acids . | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
11,
18
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
99,
110
]
} |
in spite of this high uptake , the rate of d-glucosamine incorporation into macromolecules was decreased by 60 % and the carbohydrate content of membranes ( mannose , galactose , n-acetylglucosamine , n-acetylgalactosamine , and sialic acid ) from clone ad6 was diminished by 40 to 60 % . | NA | {
"id": "C0017718",
"name": "glucosamine",
"pos": [
45,
56
]
} | {
"id": "C0001056",
"name": "n-acetylglucosamine",
"pos": [
179,
198
]
} |
evidence is presented which rules out the presence of a stable if-2 gdp complex on the surface of the 70 s ribosome following gtp hydrolysis and of any exchange reactions between if-1 and guanine nucleotides necessary for effecting the release of if-2 . | NA | {
"id": "C0018340",
"name": "gdp",
"pos": [
68,
71
]
} | {
"id": "C0018328",
"name": "guanine nucleotides",
"pos": [
188,
207
]
} |
the subsequent intravenous infusion of cholesterol contained in either rat or human high density or low density lipoproteins restored the adrenal content of cholesteryl esters and reduced the activity of 3-hydroxy-3-methylglutaryl coenzyme a reductase to basal levels . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
39,
50
]
} | {
"id": "C0008387",
"name": "cholesteryl esters",
"pos": [
157,
175
]
} |
assuming that rser and rough microsomes do not derive exclusively from different cells types , the evidence suggests that , compared to albumin and most other membrane-bound mrna 's , cytoplasmic mrna 's coding for mitoplast proteins may be preferentially segregated or compartmentalized within the cell on the microsomal class of rer . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
136,
143
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
225,
233
]
} |
in resting , non-growing human diploid fibroblasts the amount of rrna is reduced 1.8-fold , cytoplasmic polysomes are disaggregated , and the level of poly-a rna ( mrna ) is reduced 1.8-fold in relation to growing cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
39,
50
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
214,
219
]
} |
production of 5-hiaa by human umbilical vein endothelial cells was 5.4+/-2.0 nmoles per 10 ( 9 ) cells per hour ( n=5 ) and by human foreskin fibroblasts was 3.9+/-1.4 nmoles per 10 ( 9 ) cells per hour ( n=5 ) . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
142,
153
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
188,
193
]
} |
our data suggest that the protease or proteases discussed here may participate in the inactivation or degradation of a least some enzymes in tetrahymena . | NA | {
"id": "C0030946",
"name": "protease",
"pos": [
26,
34
]
} | {
"id": "C0030940",
"name": "proteases",
"pos": [
38,
47
]
} |
the effect increased with lengthening of the contact with antimetabolites , to a maximum after 20 hours ' pre-exposure , and was in part due to the shortening of the gi phase of the epithelioid elements , and in part to increasing the synchrony of the fibroblastic cells . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
0,
3
]
} | {
"id": "C0016030",
"name": "fibroblastic",
"pos": [
252,
264
]
} |
main band highly repeated dna and foldback dna replicated continuously , in contrast , satellite dna replication did not commence until three hours into s , whereupon its rate of synthesis increased ver rapidly , reaching a maximum with the next two hours . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
26,
29
]
} | {
"id": "C0012934",
"name": "satellite",
"pos": [
87,
96
]
} |
when fibrinolysis was inhibited by epsilon-aminocaproic acid ( eaca ) , cells continued to grow on the fibrin for a longer period and showed dense , criss-crossed fibroblast-type congestion . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
72,
77
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
163,
173
]
} |
plasma concentrations of progesterone ( p ) , deoxycorticosterone ( doc ) , 17-hydroxyprogesterone ( 17-oh p ) , corticosterone ( b ) , deoxycortisol ( s ) , cortisol ( f ) , and aldosterone were measured in 8 control subjects and in 10 patients with low and normal renin essential hypertension ( eh ) before and 4 and 8 h after an iv infusion of 25 units of acth . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
25,
37
]
} | {
"id": "C0020387",
"name": "17-hydroxyprogesterone",
"pos": [
76,
98
]
} |
secretion rates of 18-hydroxy-11-deoxycorticosterone ( 18-oh doc ) were measured for the 24 h prior to and the day of the acth infusions . | NA | {
"id": "C0000173",
"name": "18-hydroxy-11-deoxycorticosterone",
"pos": [
19,
52
]
} | {
"id": "C0011710",
"name": "doc",
"pos": [
61,
64
]
} |
the adenylate cyclase of two ectopic acth producing tumors ( gastric carcinoid and malignant thymoma ) was activated by trh , lh-rh , norepinephrine , epinephrine , serotonin , pge1 and mee . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
134,
148
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
151,
162
]
} |
to examine the role of catecholamines in glucopenia-induced glucagon secretion , urinary epinephrine and norepinephrine and plasma immunoreactive glucagon ( irg ) were measured during insulin-induced hypoglycemia in normal and insulin-dependent diabetic-man . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
89,
100
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
105,
119
]
} |
in contrast with other dopaminergic drugs ( l-dopa , apomorphine or bromocriptine ) a 280 mug/min dose of dopamine infused for 120 min failed to induce an increase in plasma gh in 9 normal subjects . | NA | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
23,
35
]
} | {
"id": "C0013030",
"name": "dopamine",
"pos": [
106,
114
]
} |
since dopamine does not readily cross the blood-brain barrier , these results suggest that the stimulating effect of dopaminergic drugs on gh secretion in the normal subject is exerted via the cns , whereas in acromegaly there is a direct action on structures lying outside the blood-brain barrier , probably in the hypophysis . | NA | {
"id": "C0013030",
"name": "dopamine",
"pos": [
6,
14
]
} | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
117,
129
]
} |
the study showed that the plasma cyclic amp level in normal pregnancy becomes elevated above nonpregnant level at the end of the first and during the third trimesters . | NA | {
"id": "C0032961",
"name": "pregnancy",
"pos": [
60,
69
]
} | {
"id": "C0032981",
"name": "third trimesters",
"pos": [
150,
166
]
} |
three peaks were observed , one in the void volume region ( 6 % ) , a peak in the proinsulin region ( 25 % ) , and the largest peak comigrating with insulin standard ( 69 % ) . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
82,
92
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
149,
156
]
} |
the specific activities ( cpm precipitated by anti-insulin serum/muu iri ) were 1 , 11.4 , and 3.1 for v0 , proinsulin , and insulin regions , respectively . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
108,
118
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
125,
132
]
} |
these results suggest that proinsulin is synthesized first , followed by insulin , and then the high molecular weight iri . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
27,
37
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
73,
80
]
} |
rechromatography of the high-molecular weight iri in the presence of 8m urea dissociated 90 % into smaller immunoreactive components which chromatographed in the proinsulin and insulin region . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
162,
172
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
177,
184
]
} |
these high molecular weight iri 's are not biosynthetic precursors , but either aggregates of proinsulin and insulin , or insulin bound to larger proteins . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
94,
104
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
122,
129
]
} |
in contrast , cyclic gmp excretion increased rapidly during the first trimester and remained relatively constant during the remainder of the pregnancy , reaching a peak excretion of about 140 % greater than that of normal nonpregnant women . | NA | {
"id": "C0032979",
"name": "first trimester",
"pos": [
64,
79
]
} | {
"id": "C0032961",
"name": "pregnancy",
"pos": [
141,
150
]
} |
furthermore , serum that had been depleted of dbp by treatment with sepharose containing covalently coupled antibodies against dbp was found to be depleted also of immunoreactivity against anti-gc protein antiserum . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
108,
118
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
205,
214
]
} |
inhibition of responsiveness was observed with concentrations of gst equivalent to gold levels found in serum or tissues of patients receiving chrysotherapy , inhibition was dependent upon the gold ion itself since gst and gold chloride were both inhibitory whereas thiomalic acid was not . | NA | {
"id": "C0018026",
"name": "gold",
"pos": [
83,
87
]
} | {
"id": "C0018034",
"name": "gst",
"pos": [
215,
218
]
} |
prolonged incubation of peripheral blood mononuclear cells with gst resulted in diminished mitogen responsiveness upon subsequent culture in the absence of gold . | NA | {
"id": "C0018034",
"name": "gst",
"pos": [
64,
67
]
} | {
"id": "C0018026",
"name": "gold",
"pos": [
156,
160
]
} |
we conclude that the renal vascular receptor differs sufficiently from systemic angiotensin receptors that heptapeptide analogues of aii will be useful in exploring angiotensin 's role in states characterized by disordered renal perfusion and function . | NA | {
"id": "C0003009",
"name": "aii",
"pos": [
133,
136
]
} | {
"id": "C0003018",
"name": "angiotensin 's",
"pos": [
165,
179
]
} |
absorption , excretion , and metabolism of cyolane ( phosfolan ) systemic insecticide [ ( diethoxyphosphinyl ) dithioimidocarbonic acid , cyclic ethylene ester ] in the rat . | NA | {
"id": "C0221102",
"name": "excretion",
"pos": [
13,
22
]
} | {
"id": "C0025519",
"name": "metabolism",
"pos": [
29,
39
]
} |
the composited meals for each college were analyzed for five major mineral elements -- calcium , phosphorus , magnesium , sodium , and potassium -- and five trace mineral elements -- iron , chromium , copper , manganese , and zinc . | NA | {
"id": "C0013879",
"name": "elements",
"pos": [
75,
83
]
} | {
"id": "C0031705",
"name": "phosphorus",
"pos": [
97,
107
]
} |
mononuclear cells ( mc ) from human blood were fractionated by a variety of physical and immunologic techniques , and the cellular subpopulations generated were assessed for their capacity to lyse herpes simplex virus ( hsv ) -infected target cells in the presence of igg antibody to hsv . | NA | {
"id": "C1321301",
"name": "mononuclear cells",
"pos": [
0,
17
]
} | {
"id": "C0007634",
"name": "cellular",
"pos": [
122,
130
]
} |
the method allows the quantitation of nanogram per ml concentrations of igg- and igm-anti-dnp antibodies without any physical or chemicadioimmunoassay of class-specific antibodies ( riaca ) against bsa ( viljanen et al. , 1975 ) developed recently by us . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
94,
104
]
} | {
"id": "C0021017",
"name": "class",
"pos": [
154,
159
]
} |
virus antigen is adsorbed on polystyrene balls and antibodies which attach to the antigen are detected by 125i-labeled antihuman-gamma or antihuman-mu immunoglobulins . | NA | {
"id": "C0003342",
"name": "virus antigen",
"pos": [
0,
13
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
82,
89
]
} |
by using an excess of glutaraldehyde unsaturated aldehyde groups on the film surface can react with other chemical groups predominantly with aliphatic amino groups . | NA | {
"id": "C0017814",
"name": "glutaraldehyde",
"pos": [
22,
36
]
} | {
"id": "C0001992",
"name": "aldehyde",
"pos": [
49,
57
]
} |
the cells were functionally intact and tested in a microcytotoxicity assay using embryonic fibroblasts as target cells . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
4,
9
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
91,
102
]
} |
the results presented indicate that not all proteins in the skin are capable of being the carrier protein in photoallergy of tcsa- and that cross reactivity to other halogenated salicylanilides can be explained by further photochemical reactions of tcsa- photoproducts . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
44,
52
]
} | {
"id": "C0007292",
"name": "carrier",
"pos": [
90,
97
]
} |
hydrocortisone , prednisolone , triamcinolone , betamethasone , flurometholone , paramethasone acetate , fluocinolone acetonide , fluocinonide , and flurandrenolide showed significant suppression of cantharidin-induced inflammation . | NA | {
"id": "C0016298",
"name": "fluocinolone acetonide",
"pos": [
105,
127
]
} | {
"id": "C0016299",
"name": "fluocinonide",
"pos": [
130,
142
]
} |
a number of different cross-reactions with various other polysaccharides and galactans subdivides those neuraminidase-treated glycoproteins into several subgroups , indicating that the uncovered carbohydrate structures are not always completely identical . | NA | {
"id": "C0032594",
"name": "polysaccharides",
"pos": [
57,
72
]
} | {
"id": "C0016932",
"name": "galactans",
"pos": [
77,
86
]
} |
the optimal concentration for divalent cations was 2 x 10 ( -3 ) m , for trivalent cations 1 x 10 ( -3 ) m . | NA | {
"id": "C0007448",
"name": "divalent",
"pos": [
30,
38
]
} | {
"id": "C0007447",
"name": "cations",
"pos": [
83,
90
]
} |
at times when cells infected in the absence of the lectin were liberating virus into the supernatant medium , the m or matrix protein was found in association with the plasma membrane of the lectin-treated cells . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
126,
133
]
} | {
"id": "C0023206",
"name": "lectin",
"pos": [
191,
197
]
} |
addition of cycloheximide , and inhibitor of protein synthesis , immediately after alpha-methyl-d-glucoside treatment of the cells did not alter the rate of virus production , suggesting that the proteins required for virus synthesis were available in the lectin-treated cells and that virus assembly took place without further protein synthesis on removal of the lectin . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
196,
204
]
} | {
"id": "C0023206",
"name": "lectin",
"pos": [
364,
370
]
} |
vesicular stomatitis virus ( vsv ) induces polykaryocytes in rat embryonic fibroblasts transformed by the prague strain of rous sarcoma virus ( xc cells ) . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
75,
86
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
147,
152
]
} |
( ii ) about 15 residues long , as measured by the ratio of the amount of terminal adenosine to internal adenylic acid in isolated poly ( a ) ; | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
83,
92
]
} | {
"id": "C0001465",
"name": "adenylic",
"pos": [
105,
113
]
} |
the effect of actinomycin d on the production of genomic rna , messenger rna and protein in measles virus-infected cells were investigated . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
57,
60
]
} | {
"id": "C0035696",
"name": "messenger rna",
"pos": [
63,
76
]
} |
antibodies to purified 146s particles and the cleavage peptides of vp3 showed an incomplete cross-section against vp3 peptide antigen when reacted in immunodiffusion tests , indicating that new antigenic determinants are exhibited by the peptides which are not recognized by the antiserum against the native virus proteins . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
0,
10
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
279,
288
]
} |
antibodies to purified 146s particles and the cleavage peptides of vp3 showed an incomplete cross-section against vp3 peptide antigen when reacted in immunodiffusion tests , indicating that new antigenic determinants are exhibited by the peptides which are not recognized by the antiserum against the native virus proteins . | NA | {
"id": "C0018593",
"name": "incomplete",
"pos": [
81,
91
]
} | {
"id": "C0003316",
"name": "antigenic determinants",
"pos": [
194,
216
]
} |
light and electron microscopic studies of nerves after histochemical staining for peroxidase revealed : a ) the perineurial barrier to the two peroxidases was established in 21 day normal and hcp intoxicated rats ; | NA | {
"id": "C0027021",
"name": "peroxidase",
"pos": [
82,
92
]
} | {
"id": "C0031179",
"name": "peroxidases",
"pos": [
143,
154
]
} |
b ) in animals 3-14 days , the perineurial barrier to both peroxidases was not formed and peroxidase staining was observed in the periaxonal space and in the space between paranodal loops of myelin ; | NA | {
"id": "C0031179",
"name": "peroxidases",
"pos": [
59,
70
]
} | {
"id": "C0027021",
"name": "peroxidase",
"pos": [
90,
100
]
} |
patients were evaluated by 24-hour urinary excretion of 17-ketosteroids and pregnanetriol , as well as 0900 plasma concentrations of 17-hydroxyprogesterone , progesterone , and testosterone . | NA | {
"id": "C0020387",
"name": "17-hydroxyprogesterone",
"pos": [
133,
155
]
} | {
"id": "C0033308",
"name": "progesterone",
"pos": [
158,
170
]
} |
the iodide anion tended to salt it in , raising the cloud point , while the bromide ion had no pronounced effect . | NA | {
"id": "C0021966",
"name": "iodide",
"pos": [
4,
10
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
11,
16
]
} |
a method was developed for aqueous chamber drug distribution volume measurement in the albino rabbit , and the apparent volume of distribution was determined for inulin , pilocarpine alkaloid , and 1-hexanoic acid . | NA | {
"id": "C0031923",
"name": "pilocarpine",
"pos": [
171,
182
]
} | {
"id": "C0002062",
"name": "alkaloid",
"pos": [
183,
191
]
} |
the apparent volume of distribution for pilocarpine alkaloid was 575 mul in albino eyes and 760 mul in pigmented irides ; | NA | {
"id": "C0031923",
"name": "pilocarpine",
"pos": [
40,
51
]
} | {
"id": "C0002062",
"name": "alkaloid",
"pos": [
52,
60
]
} |
for pilocarpine alkaloid , literature citations on the fraction of dose absorbed have been based on an assumed apparent volume of distribution of 250-300 mul . | NA | {
"id": "C0031923",
"name": "pilocarpine",
"pos": [
4,
15
]
} | {
"id": "C0002062",
"name": "alkaloid",
"pos": [
16,
24
]
} |
the implication of the apparent volume of distribution for pilocarpine in its ocular disposition is discussed , as is the unexpected observation that pilocarpine alkaloid apparently inhibits formation of plasmoid aqueous and follows one-compartment kinetics during these studies . | NA | {
"id": "C0031923",
"name": "pilocarpine",
"pos": [
59,
70
]
} | {
"id": "C0002062",
"name": "alkaloid",
"pos": [
162,
170
]
} |
a calculation of total body clearance suggested that pentobarbital elimination in those rats had approached portal blood flow rate-limited metabolism . | NA | {
"id": "C0221102",
"name": "elimination",
"pos": [
67,
78
]
} | {
"id": "C0025519",
"name": "metabolism",
"pos": [
139,
149
]
} |
the only significant metabolite observed in plasma was digoxin , although glucuronides and sulfates of beta-methyldigoxin , digoxin and digoxigenin also were observed in urine . | NA | {
"id": "C0025132",
"name": "beta-methyldigoxin",
"pos": [
103,
121
]
} | {
"id": "C0012265",
"name": "digoxin",
"pos": [
124,
131
]
} |
the only significant metabolite observed in plasma was digoxin , although glucuronides and sulfates of beta-methyldigoxin , digoxin and digoxigenin also were observed in urine . | NA | {
"id": "C0012265",
"name": "digoxin",
"pos": [
55,
62
]
} | {
"id": "C0012264",
"name": "digoxigenin",
"pos": [
136,
147
]
} |
the urine flow independent renal clearances of beta-methyldigoxin and derived digoxin were 59 and 206 ml/min , respectively . | NA | {
"id": "C0025132",
"name": "beta-methyldigoxin",
"pos": [
47,
65
]
} | {
"id": "C0012265",
"name": "digoxin",
"pos": [
78,
85
]
} |
arrhythmias induced by gtx i were characterized by extrasystoles whereas those induced by alpha-2h-gtx ii were characterized by initial extrasystoles followed by a failure of the atria to follow electrical stimulation . | NA | {
"id": "C0003811",
"name": "arrhythmias",
"pos": [
0,
11
]
} | {
"id": "C0340464",
"name": "extrasystoles",
"pos": [
136,
149
]
} |
an unexpected inhibition of human platelet aggregation by dopamine -- the precursor of epinephrine and norepinephrine -- is presented . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
87,
98
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
103,
117
]
} |
the bond strength of ceramco porcelain fused to nonprecious alloy n-c2 was significantly greater than that of ceramic and traditional gold-based alloys . | NA | {
"id": "C0002154",
"name": "alloy",
"pos": [
60,
65
]
} | {
"id": "C0018027",
"name": "gold",
"pos": [
134,
138
]
} |
the minimal inhibitory concentrations of penicillin , ampicillin , oxacillin , nafcillin , cephalothin , vancomycin , erythromycin and clindamycin for the two groups of streptococci were very similar in range and median values . | NA | {
"id": "C0030842",
"name": "penicillin",
"pos": [
41,
51
]
} | {
"id": "C0029983",
"name": "oxacillin",
"pos": [
67,
76
]
} |
the minimal inhibitory concentrations of penicillin , ampicillin , oxacillin , nafcillin , cephalothin , vancomycin , erythromycin and clindamycin for the two groups of streptococci were very similar in range and median values . | NA | {
"id": "C0030842",
"name": "penicillin",
"pos": [
41,
51
]
} | {
"id": "C0027324",
"name": "nafcillin",
"pos": [
79,
88
]
} |
the other aminoglycosides ( kanamycin , gentamicin and tobramycin ) offered no advantage over streptomycin in synergism with penicillin , ampicillin or vancomycin against nonenterococcal group-d streptococci or viridans streptococci . | NA | {
"id": "C0002556",
"name": "aminoglycosides",
"pos": [
10,
25
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
40,
50
]
} |
the other aminoglycosides ( kanamycin , gentamicin and tobramycin ) offered no advantage over streptomycin in synergism with penicillin , ampicillin or vancomycin against nonenterococcal group-d streptococci or viridans streptococci . | NA | {
"id": "C0002556",
"name": "aminoglycosides",
"pos": [
10,
25
]
} | {
"id": "C0038425",
"name": "streptomycin",
"pos": [
94,
106
]
} |
this assumption has ignored the fact that patients with highly bacilliferous leprosy have nasal as well as dermal infection and that , since m. leprae is shed predominantly from the nose , leprosy might be an airborne infection . | NA | {
"id": "C0037278",
"name": "dermal infection",
"pos": [
107,
123
]
} | {
"id": "C0009450",
"name": "infection",
"pos": [
218,
227
]
} |
from personal interviews obtained for 7,518 incident cases of invasive cancer from the population-based third national cancer survey , the quantitative lifetime use of cigarettes , cigars , pipes , unsmoked tobacco , wine , beer , hard liquor , and combined alcohol were recorded , as well as education and family income level . | NA | {
"id": "C0043188",
"name": "wine",
"pos": [
217,
221
]
} | {
"id": "C0001962",
"name": "alcohol",
"pos": [
258,
265
]
} |
from personal interviews obtained for 7,518 incident cases of invasive cancer from the population-based third national cancer survey , the quantitative lifetime use of cigarettes , cigars , pipes , unsmoked tobacco , wine , beer , hard liquor , and combined alcohol were recorded , as well as education and family income level . | NA | {
"id": "C0004922",
"name": "beer",
"pos": [
224,
228
]
} | {
"id": "C0001962",
"name": "alcohol",
"pos": [
258,
265
]
} |
pretreatment of rats with pyrazole or 3-amino-1,2,4-triazole ( 3-at ) known inhibitors of alcohol metabolism , profoundly inhibited the metabolism of dimethylnitrosamine ( dmn ) , both in terms of [ 14c ] co2 excretion and of the decline in the blood concentration . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
98,
108
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
209,
218
]
} |
additionally , 4-methylpyrazole , tetraethylthiuram disulfide ( disulfiram ) , methanol , and ethanol inhibited the metabolism of dmn in the whole animal . | NA | {
"id": "C0001963",
"name": "methanol",
"pos": [
79,
87
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
94,
101
]
} |
the survival and cell kinetics effect of 1,2:5,6-dianhydrogalactitol , nsc-132313 ( galactitol ) , were studied on mammalian cells . | NA | {
"id": "C0011967",
"name": "dianhydrogalactitol",
"pos": [
49,
68
]
} | {
"id": "C0013283",
"name": "galactitol",
"pos": [
84,
94
]
} |
virus-producing eb3 cells , however , contain the r component as well as vca so that the correct anti-vca titers in such cases remain in doubt . | NA | {
"id": "C0003342",
"name": "vca",
"pos": [
73,
76
]
} | {
"id": "C0003320",
"name": "vca",
"pos": [
102,
105
]
} |
since the r component , but not vca , was found to be denatured by methanol fixation , the parallel use of acetone- and methanol-fixed eb3 cell smears permitted the determination of the correct anti-vca titer . | NA | {
"id": "C0003342",
"name": "vca",
"pos": [
32,
35
]
} | {
"id": "C0003320",
"name": "vca",
"pos": [
199,
202
]
} |
all guinea pigs surviving the injection of a tumor cell-bcg mixture resisted a second tumor cell challenge . | NA | {
"id": "C0027651",
"name": "tumor",
"pos": [
45,
50
]
} | {
"id": "C0085183",
"name": "second tumor",
"pos": [
79,
91
]
} |
daily sc injections of 8 mg n6 , o2'-dibutyryl 3',5'-cyclic amp ( dbcamp ) beginning 1 day after tumor implantation significantly increased the growth rate of r32230ac rat mammary adenocarcinomas , which nearly doubled in in situ volume by day 40 compared to similarly implanted tumors in saline-injected controls . | NA | {
"id": "C0001455",
"name": "cyclic amp",
"pos": [
53,
63
]
} | {
"id": "C0012054",
"name": "dbcamp",
"pos": [
66,
72
]
} |
estramustine is a combination of estradiol and nitrogen mustard , and alone has shown objective responses in advanced prostatic cancer . | NA | {
"id": "C0014921",
"name": "estramustine",
"pos": [
0,
12
]
} | {
"id": "C0014912",
"name": "estradiol",
"pos": [
33,
42
]
} |
the intramuscular injection of cldm-2-p , 300 approximately 1800 mg daily , against suppurative ocular infections revealed excellent effects on cases of external hordeolum , acute chalazion , lid abscess , orbital phlegmone , corneal infiltration , corneal ulcer , and iridocyclitis purulenta . | NA | {
"id": "C0015403",
"name": "ocular infections",
"pos": [
96,
113
]
} | {
"id": "C0010043",
"name": "corneal ulcer",
"pos": [
249,
262
]
} |
2 ) the blood level of clindamycin following intramuscular injection of 300 mg of clindamycin-2-phosphate reached a peak of 3.3 mcg/ml at one hour later . | NA | {
"id": "C0008947",
"name": "clindamycin",
"pos": [
23,
34
]
} | {
"id": "C0055881",
"name": "clindamycin-2-phosphate",
"pos": [
82,
105
]
} |
initial recombination experiments showed a considerable potential of the ( unfractionated ) lipoprotein protein to bind to lipids and to form particles similar to native lipoproteins . | NA | {
"id": "C0023779",
"name": "lipids",
"pos": [
123,
129
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
170,
182
]
} |
whether disturbed lipid protein interactions lead to structural and/or functional alterations of the corresponding lipoproteins is a topic of discussion . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
18,
23
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
115,
127
]
} |
however , mucous acini in submandibular glands , although failing to stain with other control procedures , retained towared the absorbed antiserum , possibly through reacting with an antibody other than that for human urinary lysozyme . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
137,
146
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
183,
191
]
} |
of 14 patients with transposition complexes undergoing conduit repairs , 10 had complete transposition of the great arteries ( tga ) and 4 double-outlet right ventricle . | NA | {
"id": "C0040761",
"name": "transposition of the great arteries",
"pos": [
89,
124
]
} | {
"id": "C0013069",
"name": "double-outlet right",
"pos": [
139,
158
]
} |