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feature_name feature_name4plot category exposed Exposed (accessible surface area) accessible_surface_area bury Buried (accessible surface area) accessible_surface_area medium Medium (accessible surface area) accessible_surface_area misbad Missense badness amino_acid_feature ref_hydrophobic-side-chain:aliphatic ref AA hydrophobic-side-chain:aliphatic amino_acid_physicochemical_properties ref_positively-charged ref AA positively-charged amino_acid_physicochemical_properties ref_hydrophobic-side-chain:aromatic ref AA hydrophobic-side-chain:aromatic amino_acid_physicochemical_properties ref_special-amino-acid ref AA special-amino-acid amino_acid_physicochemical_properties hydrophobic-side-chain:aliphatic alt AA hydrophobic-side-chain:aliphatic amino_acid_physicochemical_properties polar-uncharged-side-chain alt AA polar-uncharged-side-chain amino_acid_physicochemical_properties ref_polar-uncharged-side-chain ref AA polar-uncharged-side-chain amino_acid_physicochemical_properties ref_negatively-charged ref AA negatively-charged amino_acid_physicochemical_properties special-amino-acid alt AA special-amino-acid amino_acid_physicochemical_properties negatively-charged alt AA negatively-charged amino_acid_physicochemical_properties hydrophobic-side-chain:aromatic alt AA hydrophobic-side-chain:aromatic amino_acid_physicochemical_properties positively-charged alt AA positively-charged amino_acid_physicochemical_properties cacscncon n Navs/Cavs have same AA conservation scncon n Navs have same AA conservation missingAA n missing sites gene family alignment conservation cacBEACDSFcon n HVA Cavs have same AA conservation caccon n Cavs have same AA conservation primvoltsens "S4 Voltage sensor, gating charges" functional_protein_domain pore Pore functional_protein_domain LH S4-S5 Linker helix functional_protein_domain inactivation_gate Inactivation gate functional_protein_domain SF Selectivity filter functional_protein_domain gating_break Gating break functional_protein_domain scn is sodium channel is_sodium_channel hmmpanther:PTHR10037:SF139 hmmpanther:PTHR10037:SF139 protein_domain hmmpanther:PTHR10037:SF188 hmmpanther:PTHR10037:SF188 protein_domain Pfam_domain:PF11933 Pfam domain:PF11933 protein_domain Pfam_domain:PF06512 Pfam domain:PF06512 protein_domain B "in isolated beta-bridge (secondary structure, DSSP)" secondary_structure E "anti-parallel beta-sheet (secondary structure, DSSP)" secondary_structure L "loop (secondary structure, DSSP)" secondary_structure G "3-turn helix (secondary structure, DSSP)" secondary_structure T "hydrogen bonded turn (secondary structure, DSSP)" secondary_structure I "5-turn (pi) helix (secondary structure, DSSP)" secondary_structure S "bend (secondary structure, DSSP)" secondary_structure H "4-turn (alpha) helix (secondary structure, DSSP)" secondary_structure S4M4 IVS4 structural_protein_domain Cytopl Cytoplasm structural_protein_domain Extrac Extracellular structural_protein_domain S6M2 IIS6 structural_protein_domain S1M4 IVS1 structural_protein_domain S4M2 IIS4 structural_protein_domain S6M4 IVS6 structural_protein_domain S2M1 IS2 structural_protein_domain S1M1 IS1 structural_protein_domain S3M1 IS3 structural_protein_domain S4M1 IS4 structural_protein_domain S5M1 IS5 structural_protein_domain S6M1 IS6 structural_protein_domain S1M2 IIS1 structural_protein_domain S2M2 IIS2 structural_protein_domain S3M2 IIS3 structural_protein_domain S5M2 IIS5 structural_protein_domain S1M3 IIIS1 structural_protein_domain S2M3 IIIS2 structural_protein_domain S3M3 IIIS3 structural_protein_domain S4M3 IIIS4 structural_protein_domain S5M3 IIIS5 structural_protein_domain S6M3 IIIS6 structural_protein_domain S2M4 IVS2 structural_protein_domain S3M4 IVS3 structural_protein_domain S5M4 IVS5 structural_protein_domain densgof GOF variant density other Navs/Cavs 10aa window variant_density densdiscovehrSCN discovEHR variant density other Navs variant_density denslof LOF variant density other Navs/Cavs 10aa window variant_density densdiscovehrCAC discovEHR variant density other Cavs variant_density densdiscovehr discovEHR variant density other Navs/Cavs variant_density densgnomad gnomAD variant density other Navs/Cavs variant_density Prints_domain:PR01632 Prints domain:PR01632 protein_domain 5.scn Navs/Cavs specific conservation 5%-CI conservation 50.scn Navs/Cavs specific conservation 50%-CI conservation 95.scn Navs/Cavs specific conservation 95%-CI conservation 5.scncac Navs/Cavs joined conservation 5%-CI conservation 50.scncac Navs/Cavs joined conservation 50%-CI conservation 95.scncac Navs/Cavs joined conservation 95%-CI conservation densgof3aa GOF variant density other Navs/Cavs 3aa window variant_density denslof3aa LOF variant density other Navs/Cavs 3aa window variant_density lofsotherSCNgenes LOF variants in other Navs variant_density lofsotherCACgenes LOF variants in other Cavs variant_density gofsotherSCNgenes GOF variants in other Navs variant_density gofsotherCACgenes GOF variants in other Cavs variant_density CTD C-terminal domain structural_protein_domain SF_DEKA "Selectivity filter, DEKA motif" functional_protein_domain grantham Grantham score amino_acid_feature BLOSUM BLOSUM score amino_acid_feature alphahelix_prop_altAA alt AA alpha-helical propensity (kJ/mol) amino_acid_physicochemical_properties alphahelix_prop_refAA ref AA alpha-helical propensity (kJ/mol) amino_acid_physicochemical_properties hydrophobicity_refAA ref AA hydrophobicity 1 amino_acid_physicochemical_properties hydrophobicity_altAA alt AA hydrophobicity 1 amino_acid_physicochemical_properties hydrophobicity2_refAA ref AA hydrophobicity 2 amino_acid_physicochemical_properties hydrophobicity2_altAA alt AA hydrophobicity 2 amino_acid_physicochemical_properties hydrophobicity3_refAA ref AA hydrophobicity 3 amino_acid_physicochemical_properties hydrophobicity3_altAA alt AA hydrophobicity 3 amino_acid_physicochemical_properties hydrophobicity4_refAA ref AA hydrophobicity 4 amino_acid_physicochemical_properties hydrophobicity4_altAA alt AA hydrophobicity 4 amino_acid_physicochemical_properties densgofwovar3aa GOF variant density other Navs/Cavs 3aa window variant_density denslofwovar3aa LOF variant density other Navs/Cavs 3aa window variant_density densgofwovar GOF variant density other Navs/Cavs 10aa window variant_density denslofwovar LOF variant density other Navs/Cavs 10aa window variant_density |