sentence1: Loss of Wnt5a and Wnt11 leads to a dramatic loss of second heart field progenitors in the developing heart.
sentence2: This loss of Wnt5a and Wnt11 is accompanied by an increase in Wnt/β-catenin signaling, and ectopic Wnt5a/Wnt11 inhibits β-catenin signaling and promotes cardiac progenitor development in differentiating embryonic stem cells.