passages.id: PMID-8215620__text
passages.type: abstract
passages.text: Methotrexate osteopathy in rheumatic disease.
  OBJECTIVE:
  To determine whether two adults with stress fractures receiving low weekly doses of methotrexate had methotrexate osteopathy.
  CASE REPORTS:
  Two adult patients developed features consistent with methotrexate osteopathy while receiving low weekly doses of methotrexate.
  METHODS:
  Iliac crest biopsy samples were taken and bone histomorphometry carried out.
  RESULTS:
  Symptoms resolved when the methotrexate was discontinued. Bone histology showed changes consistent with osteoblast inhibition by methotrexate.
  CONCLUSIONS:
  When given in low doses for prolonged periods, methotrexate may have adverse effects on bone, particularly in post-menopausal women.
  