text: Changes of lymphocyte subsets in leukemia patients who received allogenic bone marrow transplantation.
  Proportional changes of lymphocyte subsets in the peripheral blood were monitored by two-color flow-cytometry in seven leukemia patients who had received allogenic bone marrow transplantation (BMT). Lymphocyte counts, and proportions of T and B-cells returned to normal ranges between the 2nd and 12th months after BMT. Activated T-cells prominently increased after BMT, and the values gradually returned toward normal. As to lymphocyte subsets, the proportions of CD 4+ cells had remained low, while those of CD 8+ cells high for a whole observation period after BMT. The changes of CD 4+ cells were caused by the decrease of suppressor-inducer T-cells (CD 4+ Leu 8+). High proportion of CD 8+ cells was mainly associated with increased suppressor T-cells (CD 8+ CD 11+). Among natural killer (NK) cells, highly active NK cells (CD 16+ CD 57-) markedly increased shortly after BMT, and gradually returned to normal. CD 16 -CD 57+ NK cells increased beyond normal ranges after the 2nd month. The incidence or degree of acute and chronic graft-versus-host diseases (GVHD) did not correlate with the changes of any lymphocyte subsets. The present results suggest that the increase of activated T-cells shortly after BMT reflects lymphocyte reconstitution. The prolonged immune deficiency after BMT might be related to either deficient expression of homing receptor (Leu 8 antigen) on CD 4+ cells or increased suppressor T-cells (CD 8+ CD 11+). In addition, the early increase of NK cells after BMT may compensate for the immune deficiency in BMT patients.
  
entities.text: ['lymphocyte']
entities.type: Cell
entities.entity_id: PMID-1683740_T1
entities.text: ['bone marrow']
entities.type: Multi-tissue_structure
entities.entity_id: PMID-1683740_T2
entities.text: ['lymphocyte']
entities.type: Cell
entities.entity_id: PMID-1683740_T3
entities.text: ['peripheral blood']
entities.type: Organism_substance
entities.entity_id: PMID-1683740_T4
entities.text: ['bone marrow']
entities.type: Multi-tissue_structure
entities.entity_id: PMID-1683740_T5
entities.text: ['Lymphocyte']
entities.type: Cell
entities.entity_id: PMID-1683740_T6
entities.text: ['T']
entities.type: Cell
entities.entity_id: PMID-1683740_T7
entities.text: ['B-cells']
entities.type: Cell
entities.entity_id: PMID-1683740_T8
entities.text: ['T-cells']
entities.type: Cell
entities.entity_id: PMID-1683740_T9
entities.text: ['lymphocyte']
entities.type: Cell
entities.entity_id: PMID-1683740_T10
entities.text: ['CD 4+ cells']
entities.type: Cell
entities.entity_id: PMID-1683740_T11
entities.text: ['CD 8+ cells']
entities.type: Cell
entities.entity_id: PMID-1683740_T12
entities.text: ['CD 4+ cells']
entities.type: Cell
entities.entity_id: PMID-1683740_T13
entities.text: ['suppressor-inducer T-cells']
entities.type: Cell
entities.entity_id: PMID-1683740_T14
entities.text: ['CD 8+ cells']
entities.type: Cell
entities.entity_id: PMID-1683740_T15
entities.text: ['suppressor T-cells']
entities.type: Cell
entities.entity_id: PMID-1683740_T16
entities.text: ['natural killer (NK) cells']
entities.type: Cell
entities.entity_id: PMID-1683740_T17
entities.text: ['NK cells']
entities.type: Cell
entities.entity_id: PMID-1683740_T18
entities.text: ['CD 16 -CD 57+ NK cells']
entities.type: Cell
entities.entity_id: PMID-1683740_T19
entities.text: ['lymphocyte']
entities.type: Cell
entities.entity_id: PMID-1683740_T20
entities.text: ['T-cells']
entities.type: Cell
entities.entity_id: PMID-1683740_T21
entities.text: ['lymphocyte']
entities.type: Cell
entities.entity_id: PMID-1683740_T22
entities.text: ['CD 4+ cells']
entities.type: Cell
entities.entity_id: PMID-1683740_T23
entities.text: ['suppressor T-cells']
entities.type: Cell
entities.entity_id: PMID-1683740_T24
entities.text: ['NK cells']
entities.type: Cell
entities.entity_id: PMID-1683740_T25
entities.text: ['graft']
entities.type: Multi-tissue_structure
entities.entity_id: PMID-1683740_T26