text: Anaplastic and sarcomatoid carcinoma of the small intestine: a clinicopathologic study.
  Carcinomas involving the jejunum and ileum are rare tumors. During a review of small intestinal neoplasms, six primary carcinomas of jejunum or ileum with an anaplastic and sarcomatoid histology were identified. At presentation, three of the patients had symptoms related to metastatic disease and three had symptoms referable to the local tumor. The tumors were large (greater than 4.5 cm in diameter), usually endophytic masses composed of large cells with eosinophilic cytoplasm, anaplastic nuclei, and prominent nucleoli. In many areas, the cells had a spindled configuration. Mucin positivity was identified in all six cases. Electron microscopic findings in two cases were indicative of epithelial differentiation. The tumors behaved aggressively; all five patients for whom there was clinical follow-up died of metastases within 40 months. The six anaplastic and sarcomatoid carcinomas were compared with 29 typical adenocarcinomas arising in the jejunum or ileum. Only two of the latter group had symptoms referable to distant metastases at presentation. These tumors also tended to be smaller at presentation (11 tumors were less than 4 cm in greatest dimension). Of 25 patients with typical adenocarcinomas who had acceptable follow-up, 18 (72%) died of disease and five (20%) were alive with no evidence of disease after 5 years. We conclude that anaplastic and sarcomatoid carcinoma is a rare variant of small intestinal carcinoma with an aggressive clinical course.
  
entities.text: ['Anaplastic and sarcomatoid carcinoma']
entities.type: Pathological_formation
entities.entity_id: PMID-2777242_T1
entities.text: ['small intestine']
entities.type: Organ
entities.entity_id: PMID-2777242_T2
entities.text: ['Carcinomas']
entities.type: Pathological_formation
entities.entity_id: PMID-2777242_T3
entities.text: ['jejunum']
entities.type: Multi-tissue_structure
entities.entity_id: PMID-2777242_T4
entities.text: ['ileum']
entities.type: Multi-tissue_structure
entities.entity_id: PMID-2777242_T5
entities.text: ['tumors']
entities.type: Pathological_formation
entities.entity_id: PMID-2777242_T6
entities.text: ['small intestinal neoplasms']
entities.type: Pathological_formation
entities.entity_id: PMID-2777242_T7
entities.text: ['carcinomas']
entities.type: Pathological_formation
entities.entity_id: PMID-2777242_T8
entities.text: ['jejunum']
entities.type: Multi-tissue_structure
entities.entity_id: PMID-2777242_T9
entities.text: ['ileum']
entities.type: Multi-tissue_structure
entities.entity_id: PMID-2777242_T10
entities.text: ['sarcomatoid']
entities.type: Pathological_formation
entities.entity_id: PMID-2777242_T11
entities.text: ['tumor']
entities.type: Pathological_formation
entities.entity_id: PMID-2777242_T12
entities.text: ['tumors']
entities.type: Pathological_formation
entities.entity_id: PMID-2777242_T13
entities.text: ['cells']
entities.type: Cell
entities.entity_id: PMID-2777242_T14
entities.text: ['eosinophilic cytoplasm']
entities.type: Organism_substance
entities.entity_id: PMID-2777242_T15
entities.text: ['nuclei']
entities.type: Cellular_component
entities.entity_id: PMID-2777242_T16
entities.text: ['nucleoli']
entities.type: Cellular_component
entities.entity_id: PMID-2777242_T17
entities.text: ['cells']
entities.type: Cell
entities.entity_id: PMID-2777242_T18
entities.text: ['epithelial']
entities.type: Tissue
entities.entity_id: PMID-2777242_T19
entities.text: ['tumors']
entities.type: Pathological_formation
entities.entity_id: PMID-2777242_T20
entities.text: ['metastases']
entities.type: Pathological_formation
entities.entity_id: PMID-2777242_T21
entities.text: ['anaplastic and sarcomatoid carcinomas']
entities.type: Pathological_formation
entities.entity_id: PMID-2777242_T22
entities.text: ['adenocarcinomas']
entities.type: Pathological_formation
entities.entity_id: PMID-2777242_T23
entities.text: ['jejunum']
entities.type: Multi-tissue_structure
entities.entity_id: PMID-2777242_T24
entities.text: ['ileum']
entities.type: Multi-tissue_structure
entities.entity_id: PMID-2777242_T25
entities.text: ['metastases']
entities.type: Pathological_formation
entities.entity_id: PMID-2777242_T26
entities.text: ['tumors']
entities.type: Pathological_formation
entities.entity_id: PMID-2777242_T27
entities.text: ['tumors']
entities.type: Pathological_formation
entities.entity_id: PMID-2777242_T28
entities.text: ['adenocarcinomas']
entities.type: Pathological_formation
entities.entity_id: PMID-2777242_T29
entities.text: ['anaplastic and sarcomatoid carcinoma']
entities.type: Pathological_formation
entities.entity_id: PMID-2777242_T30
entities.text: ['small intestinal carcinoma']
entities.type: Pathological_formation
entities.entity_id: PMID-2777242_T31