text: Neutrophil function in chronic neutrophilic leukemia: defective respiratory burst in response to phorbol esters.
  Functional analyses were performed on neutrophils isolated from 6 patients from two institutions who displayed features of chronic neutrophilic leukemia (CNL). These neutrophils demonstrated a consistent deficiency (44 +/- 8% of control values) in superoxide anion (O2-) production in response to the phorbol ester, phorbol myristate acetate (PMA). O2- production in response to chemotactic peptides was near normal (82.3 +/- 10.7% of control values). Bacterial killing was normal in the two patients studied, and chemotaxis was diminished in response to zymosan-activated plasma and to high concentrations of chemotactic peptides in the patients studied. Cytosolic C kinase activity was decreased in one of the two patients studied. These results suggest that a deficient O2- release in response to PMA is a hallmark of neutrophils in CNL and may provide a diagnostic indicator of this condition.
  
entities: ['Neutrophil']
entities: Cell
entities: PMID-1316705_T1
entities: ['neutrophilic']
entities: Cell
entities: PMID-1316705_T2
entities: ['respiratory']
entities: Anatomical_system
entities: PMID-1316705_T3
entities: ['neutrophils']
entities: Cell
entities: PMID-1316705_T4
entities: ['neutrophilic']
entities: Cell
entities: PMID-1316705_T5
entities: ['neutrophils']
entities: Cell
entities: PMID-1316705_T6
entities: ['plasma']
entities: Organism_substance
entities: PMID-1316705_T7
entities: ['neutrophils']
entities: Cell
entities: PMID-1316705_T8