text: Effects of hypertension and sympathetic denervation on cerebral blood flow in newborn pigs.
  To investigate the potential role of sympathetic nerves in preventing pronounced increases in cerebral blood flow, we evaluated the effects of abrupt hypertension on the cerebral circulation of newborn pigs with intact cerebral sympathetic innervation and after cerebral sympathetic denervation. Epinephrine infusion was used to induce abrupt increases in mean (+/- SEM) arterial pressure (innervated pigs, 62 +/- 3 mm of Hg to 115 +/- 3 mm of Hg; denervated pigs, 71 +/- 4 mm of Hg to 132 +/- 4 mm of Hg) that remained increased for the 3 minutes of the study. Abrupt hypertension increased blood flow to all brain regions. In denervated pigs, the increased flow to the cerebrum was prolonged, compared with that in pigs with intact sympathetic innervation. Differences between pigs of the innervated and denervated groups were not apparent, with respect to blood flow to any other region (caudate region, brain stem, cerebellum). In newborn pigs, sympathetic nerves may attenuate hypertension-induced increases in blood flow to the cerebrum, but do not appear to affect flow to the rest of the brain.
  
entities: ['cerebral']
entities: Organ
entities: PMID-2729721_T1
entities: ['blood']
entities: Organism_substance
entities: PMID-2729721_T2
entities: ['cerebral']
entities: Organ
entities: PMID-2729721_T3
entities: ['blood']
entities: Organism_substance
entities: PMID-2729721_T4
entities: ['cerebral']
entities: Organ
entities: PMID-2729721_T5
entities: ['cerebral']
entities: Organ
entities: PMID-2729721_T6
entities: ['cerebral']
entities: Organ
entities: PMID-2729721_T7
entities: ['blood']
entities: Organism_substance
entities: PMID-2729721_T8
entities: ['brain']
entities: Organ
entities: PMID-2729721_T9
entities: ['cerebrum']
entities: Multi-tissue_structure
entities: PMID-2729721_T10
entities: ['brain stem']
entities: Multi-tissue_structure
entities: PMID-2729721_T11
entities: ['cerebellum']
entities: Multi-tissue_structure
entities: PMID-2729721_T12
entities: ['nerves']
entities: Multi-tissue_structure
entities: PMID-2729721_T13
entities: ['blood']
entities: Organism_substance
entities: PMID-2729721_T14
entities: ['cerebrum']
entities: Multi-tissue_structure
entities: PMID-2729721_T15
entities: ['brain']
entities: Organ
entities: PMID-2729721_T16
entities: ['nerves']
entities: Multi-tissue_structure
entities: PMID-2729721_T17
entities: ['blood']
entities: Organism_substance
entities: PMID-2729721_T18
entities: ['arterial']
entities: Multi-tissue_structure
entities: PMID-2729721_T19