text: Methotrexate osteopathy in rheumatic disease.
  OBJECTIVE:
  To determine whether two adults with stress fractures receiving low weekly doses of methotrexate had methotrexate osteopathy.
  CASE REPORTS:
  Two adult patients developed features consistent with methotrexate osteopathy while receiving low weekly doses of methotrexate.
  METHODS:
  Iliac crest biopsy samples were taken and bone histomorphometry carried out.
  RESULTS:
  Symptoms resolved when the methotrexate was discontinued. Bone histology showed changes consistent with osteoblast inhibition by methotrexate.
  CONCLUSIONS:
  When given in low doses for prolonged periods, methotrexate may have adverse effects on bone, particularly in post-menopausal women.
  
entities: ['Iliac crest biopsy samples']
entities: Multi-tissue_structure
entities: PMID-8215620_T1
entities: ['bone']
entities: Tissue
entities: PMID-8215620_T2
entities: ['Bone']
entities: Tissue
entities: PMID-8215620_T3
entities: ['osteoblast']
entities: Cell
entities: PMID-8215620_T4
entities: ['bone']
entities: Organ
entities: PMID-8215620_T5